Hi Christopher,
I will answer with a qualified yes. Depending on your willingness to try new things and the availability of a good helper you can install a new windshield. We had both windshields in our GM 4106 replaced by professionals and I watched them do it, one on the inside and one on the outside. After that I installed 10 windows in the sides of our Prevost Le Mirage XL alone. I bought the special tool for installing the spline into the gasket surrounding the glass and that made that job a lot easier. Be sure to apply plenty of soapy water to the gasket and glass to facilitate the job and take your time. I made my own tools for helping get the glass into the gasket out of plastic about 1/4" thick by 1 1/4" wide and 6" long. I sanded a long tapper on one flat side and rounded the nose on each one. My first try I used wood tools but they kept breaking so I went to the plastic ones and had no further problems. I also used a scaffold to work from and that made the job easier and safer.
Good luck, Sam 4106